All life that we know of has to struggle to survive.
Either we're fighting the elements for food and shelter, or we're fighting each other in wars, or we're struggling to out compete our neighbors economically as population increases and living expenses grow.
When we have achieved all our needs like in our present age, half of us will get sick and try to destroy the other half. This is what liberalism is.
Transhumanism won't stop the fundamental principle of the struggle to survive. It will just change the battleground into some other venue.
My suggestion is that the only solution is religion, specifically a new religion is needed that is based on DNA.
The reason DNA is sacred is because the only way you get it is through pure suffering. Think about it, how many had to die, and under what horrible conditions, did it take for us to get to where we are today? You can't simulate it on a computer and come up with your own DNA, because there are so many variables that only something that is actually alive can create it. Its nearly impossible to even simulate a couple hundred neurons, much less a brain, much less the DNA that created the brain as a mere tool to propagate itself.
The nice thing about religion is that it takes the struggle that is necessary for life, and it turns it into a personal struggle against sin. So it makes the battleground inside your own mind, and the entire religion is designed to give you training on how to take it on.
That way, you can have life while at the same time reducing the need for as much physical death and suffering (be it from the elements, wars, or self inflicted destruction via lefism) that would normally be required, since you paid it forward and fought the war internally on your own terms.
So my only caution to you with the transhumanism stuff is that there is literally no example of life without suffering that we know of, and you'd need pretty strong reasoning or evidence as to why you can have life without that element before simply assuming its possible.
Btw, I know you hate big chunks of text, sorry about this.