Quote Originally Posted by PatColo View Post
RE Max's vid ^ above, at 18:55, Dr. Jane Ruby (yes I know, (((Rubenstein)))) speaks of this acronym: "SPIONS" - stands for (notice the cap/bold letters):
SuPramagnetic Iron Oxide NanoparticleS

^ so they had to really bend over backwards, picking P & S letters out of the middle & end of the abbreviated words, to get their desired acronym: SPIONS, coz they Spy-Ons... US, right?

I mean, wouldn't "SMIONP", or maybe just the easier to speak "SMION" coz "Nanoparticle" is a legit single word, be more appropriate acronym choices, given the main + modifier words?
Surpa-Magnetic Iron Oxide NanoParticles

Apparently not... they jumped through extra, unlikely
hoops to get their desired "Spy-Ons" sounding acronym. Wonder why?

I looked up "Supramagnetic" as Dr Ruby enunciated it above - meaning I just typed it into duckduckgo & watched what results came up. No evidence that it's a legit stand alone word; but what DOES populate the top results is this word "Superparamagnetic", which would explain the otherwise unlikely "SPIONS" acronym:

SuperParamagnetic Iron Oxide NanoparticleS

as in: https://pubmed.ncbi.nlm.nih.gov/24715289/


Methods Mol Biol. 2014;1143:181-94.
doi: 10.1007/978-1-4939-0410-5_12.

Superparamagnetic nanoparticle delivery of DNA vaccine

Fatin Nawwab Al-Deen 1, Cordelia Selomulya, Charles Ma, Ross L Coppel

Affiliations expand




Abstract

The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo. In particular, the duration for gene transfection especially for in vitro application can be significantly reduced by magnetofection compared to the time required to achieve high gene transfection with standard protocols. SPIONs that have been rendered stable in physiological conditions can be used as both therapeutic and diagnostic agents due to their unique magnetic characteristics. Valuable features of iron oxide nanoparticles in bioapplications include a tight control over their size distribution, magnetic properties of these particles, and the ability to carry particular biomolecules to specific targets. The internalization and half-life of the particles within the body depend upon the method of synthesis. Numerous synthesis methods have been used to produce magnetic nanoparticles for bioapplications with different sizes and surface charges. The most common method for synthesizing nanometer-sized magnetite Fe3O4 particles in solution is by chemical coprecipitation of iron salts. The coprecipitation method is an effective technique for preparing a stable aqueous dispersions of iron oxide nanoparticles. We describe the production of Fe3O4-based SPIONs with high magnetization values (70 emu/g) under 15 kOe of the applied magnetic field at room temperature, with 0.01 emu/g remanence via a coprecipitation method in the presence of trisodium citrate as a stabilizer. Naked SPIONs often lack sufficient stability, hydrophilicity, and the capacity to be functionalized. In order to overcome these limitations, polycationic polymer was anchored on the surface of freshly prepared SPIONs by a direct electrostatic attraction between the negatively charged SPIONs (due to the presence of carboxylic groups) and the positively charged polymer. Polyethylenimine was chosen to modify the surface of SPIONs to assist the delivery of plasmid DNA into mammalian cells due to the polymer's extensive buffering capacity through the "proton sponge" effect.

^ So it seems Dr Jane Ruby misspoke above; no question now what SPIONs is.

& strike my 'paranoid' comment above re "Spy-Ons", though it is an awfully convenient cohencidence.

Can someone decipher a publication date from all those numbers around the study's title? I see a "2014" there but if month/day is also encoded with it somehow, it aint clear how. & I'm just guessing re "2014" being the year.

ziopedia on superparamagnetism:
https://en.wikipedia.org/wiki/Superparamagnetism